TY  - GEN
AU  - Jossé,Rozenn
AU  - Martin,Scott E
AU  - Guha,Rajarshi
AU  - Ormanoglu,Pinar
AU  - Pfister,Thomas D
AU  - Reaper,Philip M
AU  - Barnes,Christopher S
AU  - Jones,Julie
AU  - Charlton,Peter
AU  - Pollard,John R
AU  - Morris,Joel
AU  - Doroshow,James H
AU  - Pommier,Yves
TI  - ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses
SN  - 1538-7445
PY  - 2015///0304
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - antagonists & inhibitors
KW  - Camptothecin
KW  - analogs & derivatives
KW  - Cell Line, Tumor
KW  - Checkpoint Kinase 1
KW  - DNA Damage
KW  - DNA Replication
KW  - drug effects
KW  - DNA Topoisomerases, Type I
KW  - metabolism
KW  - HT29 Cells
KW  - Histones
KW  - genetics
KW  - Humans
KW  - Irinotecan
KW  - Organothiophosphorus Compounds
KW  - pharmacology
KW  - Phosphorylation
KW  - Protein Kinases
KW  - Pyrazines
KW  - Replication Origin
KW  - Single-Cell Analysis
KW  - methods
KW  - Sulfones
KW  - Topoisomerase I Inhibitors
KW  - Topotecan
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/0008-5472.CAN-13-3369
ER  -