Jossé, Rozenn <br/><br/>
ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.  [electronic resource] 

 -  Cancer research  Dec 2014 
 - 6968-79 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1538-7445 
<br/><br/><label>Standard No.: </label>10.1158/0008-5472.CAN-13-3369  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Ataxia Telangiectasia Mutated Proteins--antagonists & inhibitors<br/>Camptothecin--analogs & derivatives<br/>Cell Line, Tumor<br/>Checkpoint Kinase 1<br/>DNA Damage<br/>DNA Replication--drug effects<br/>DNA Topoisomerases, Type I--metabolism<br/>HT29 Cells<br/>Histones--genetics<br/>Humans<br/>Irinotecan<br/>Organothiophosphorus Compounds--pharmacology<br/>Phosphorylation--drug effects<br/>Protein Kinases--genetics<br/>Pyrazines--pharmacology<br/>Replication Origin--drug effects<br/>Single-Cell Analysis--methods<br/>Sulfones--pharmacology<br/>Topoisomerase I Inhibitors--pharmacology<br/>Topotecan--pharmacology