TY  - GEN
AU  - Ott,Heidi M
AU  - Graves,Alan P
AU  - Pappalardi,Melissa B
AU  - Huddleston,Michael
AU  - Halsey,Wendy S
AU  - Hughes,Ashley M
AU  - Groy,Arthur
AU  - Dul,Edward
AU  - Jiang,Yong
AU  - Bai,Yuchen
AU  - Annan,Roland
AU  - Verma,Sharad K
AU  - Knight,Steven D
AU  - Kruger,Ryan G
AU  - Dhanak,Dashyant
AU  - Schwartz,Benjamin
AU  - Tummino,Peter J
AU  - Creasy,Caretha L
AU  - McCabe,Michael T
TI  - A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation
SN  - 1538-8514
PY  - 2015///0811
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Binding Sites
KW  - Cell Line, Tumor
KW  - Cluster Analysis
KW  - Enhancer of Zeste Homolog 2 Protein
KW  - Gene Expression
KW  - Gene Expression Profiling
KW  - Gene Silencing
KW  - Heterozygote
KW  - Histones
KW  - metabolism
KW  - Humans
KW  - Lysine
KW  - Methylation
KW  - Models, Molecular
KW  - Molecular Sequence Data
KW  - Mutation
KW  - Polycomb Repressive Complex 2
KW  - chemistry
KW  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
KW  - genetics
KW  - Protein Conformation
KW  - Sequence Alignment
KW  - Substrate Specificity
KW  - Transcriptional Activation
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1158/1535-7163.MCT-13-0876
ER  -