Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors. [electronic resource]
- The Journal of biological chemistry Nov 2014
- 31513-25 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M114.606483 doi
Antineoplastic Agents--chemistry BH3 Interacting Domain Death Agonist Protein--metabolism Binding Sites Camptothecin--chemistry Cell Cycle Cell Line, Tumor Cell Survival Checkpoint Kinase 1 DNA Repair Down-Regulation Drug Resistance Fibroblasts--metabolism Gene Expression Regulation, Neoplastic Humans Phosphorylation Promoter Regions, Genetic Protein Kinases--metabolism RNA Interference RNA, Small Interfering--metabolism Replication Protein A--metabolism S Phase Signal Transduction Topoisomerase I Inhibitors--chemistry Transcription Factors--metabolism Zinc Finger Protein GLI1