Tripathi, Kaushlendra

Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors. [electronic resource] - The Journal of biological chemistry Nov 2014 - 31513-25 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M114.606483 doi


Antineoplastic Agents--chemistry
BH3 Interacting Domain Death Agonist Protein--metabolism
Binding Sites
Camptothecin--chemistry
Cell Cycle
Cell Line, Tumor
Cell Survival
Checkpoint Kinase 1
DNA Repair
Down-Regulation
Drug Resistance
Fibroblasts--metabolism
Gene Expression Regulation, Neoplastic
Humans
Phosphorylation
Promoter Regions, Genetic
Protein Kinases--metabolism
RNA Interference
RNA, Small Interfering--metabolism
Replication Protein A--metabolism
S Phase
Signal Transduction
Topoisomerase I Inhibitors--chemistry
Transcription Factors--metabolism
Zinc Finger Protein GLI1