Fernandez, Marty A <br/><br/>
Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.  [electronic resource] 

 -  The Journal of biological chemistry  Nov 2014 
 - 31043-52 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M114.581165  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--genetics<br/>Amyloid Precursor Protein Secretases--metabolism<br/>Amyloid beta-Peptides--physiology<br/>Animals<br/>CHO Cells<br/>Carboxypeptidases--metabolism<br/>Cricetinae<br/>Cricetulus<br/>Enzyme-Linked Immunosorbent Assay<br/>Kinetics<br/>Mutation<br/>Peptide Fragments--physiology<br/>Presenilin-1--genetics<br/>Protein Structure, Tertiary<br/>Proteolysis