TY - GEN AU - Liu,Ling AU - Zeng,Wei AU - Wortinger,Mark A AU - Yan,S Betty AU - Cornwell,Paul AU - Peek,Victoria L AU - Stephens,Jennifer R AU - Tetreault,Jonathan W AU - Xia,Jinqi AU - Manro,Jason R AU - Credille,Kelly M AU - Ballard,Darryl W AU - Brown-Augsburger,Patricia AU - Wacheck,Volker AU - Chow,Chi-Kin AU - Huang,Lihua AU - Wang,Yong AU - Denning,Irene AU - Davies,Julian AU - Tang,Ying AU - Vaillancourt,Peter AU - Lu,Jirong TI - LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth SN - 1557-3265 PY - 2015///0728 KW - Animals KW - Antibodies, Monoclonal KW - administration & dosage KW - Antibodies, Monoclonal, Humanized KW - pharmacology KW - Antibodies, Neutralizing KW - Antineoplastic Agents KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Disease Models, Animal KW - Down-Regulation KW - Enzyme Activation KW - Female KW - Hepatocyte Growth Factor KW - metabolism KW - Humans KW - Macaca fascicularis KW - Male KW - Mice KW - Neoplasms KW - drug therapy KW - Phosphorylation KW - Protein Transport KW - Proteolysis KW - Proto-Oncogene Proteins c-met KW - antagonists & inhibitors KW - Tumor Burden KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/1078-0432.CCR-14-0543 ER -