Lin, Han-Ching 5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [electronic resource] - PloS one 2014 - e107890 p. digital Publication Type: Journal Article; Research Support, Non-U.S. Gov't ISSN: 1932-6203 Standard No.: 10.1371/journal.pone.0107890 doi Subjects--Topical Terms: AnimalsArachidonate 5-Lipoxygenase--deficiencyChemokine CCL2--bloodEdema--drug therapyEnzyme Activation--drug effectsFibroblasts--drug effectsGene Knockout TechniquesHumansI-kappa B Kinase--metabolismInflammation--chemically inducedInterleukin-6--geneticsLeukotriene B4--metabolismLipoxygenase Inhibitors--pharmacologyMaleMiceMice, Inbred C57BLPhosphorylation--drug effectsProteolysis--drug effectsRNA InterferenceRNA, Small Interfering--geneticsSynovial Membrane--pathologyTumor Necrosis Factor-alpha--adverse effects