TY  - GEN
AU  - Katayama,Ryohei
AU  - Friboulet,Luc
AU  - Koike,Sumie
AU  - Lockerman,Elizabeth L
AU  - Khan,Tahsin M
AU  - Gainor,Justin F
AU  - Iafrate,A John
AU  - Takeuchi,Kengo
AU  - Taiji,Makoto
AU  - Okuno,Yasushi
AU  - Fujita,Naoya
AU  - Engelman,Jeffrey A
AU  - Shaw,Alice T
TI  - Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
SN  - 1557-3265
PY  - 2015///0709
KW  - Anaplastic Lymphoma Kinase
KW  - Benzoquinones
KW  - pharmacology
KW  - Carbazoles
KW  - Carcinoma, Non-Small-Cell Lung
KW  - diagnostic imaging
KW  - Cell Line, Tumor
KW  - Crizotinib
KW  - DNA Mutational Analysis
KW  - Dose-Response Relationship, Drug
KW  - Drug Resistance, Neoplasm
KW  - genetics
KW  - HSP90 Heat-Shock Proteins
KW  - antagonists & inhibitors
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Lactams, Macrocyclic
KW  - Lung Neoplasms
KW  - Models, Molecular
KW  - Mutation
KW  - Piperidines
KW  - Protein Conformation
KW  - Protein Kinase Inhibitors
KW  - Pyrazoles
KW  - Pyridines
KW  - Receptor Protein-Tyrosine Kinases
KW  - Tomography, X-Ray Computed
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1078-0432.CCR-14-1511
ER  -