Wang, Chih-Ya

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression. [electronic resource] - Oncotarget Oct 2014 - 9838-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.2451 doi


Angiogenesis Inhibitors--pharmacology
Animals
Apoptosis--drug effects
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Proliferation--drug effects
Colonic Neoplasms--blood supply
Female
G1 Phase Cell Cycle Checkpoints--drug effects
HCT116 Cells
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Hydroxamic Acids--pharmacology
Indoles--pharmacology
Male
Mice
Mice, Nude
Mice, SCID
Neovascularization, Pathologic--drug therapy
Signal Transduction
Tissue Inhibitor of Metalloproteinase-3--antagonists & inhibitors
Up-Regulation--drug effects
Xenograft Model Antitumor Assays