Peterson, Kenneth R

A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies. [electronic resource] - PloS one 2014 - e107006 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0107006 doi


Animals
Antigens, CD34--metabolism
Bone Marrow Cells--drug effects
Chromosomes, Artificial, Yeast
Drug Discovery
Drug Evaluation, Preclinical
Erythroid Precursor Cells--drug effects
Fetal Hemoglobin--biosynthesis
Gene Expression Regulation--drug effects
Gene Targeting
Genes, Reporter
Genetic Loci
Genetic Vectors--genetics
Hemoglobinopathies--drug therapy
High-Throughput Screening Assays
Humans
Mice
Mice, Transgenic
beta-Globins--biosynthesis
gamma-Globins--biosynthesis