Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1. [electronic resource]
- PloS one 2014
- e107432 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0107432 doi
Antineoplastic Agents--chemical synthesis Benzimidazoles--chemical synthesis Catalytic Domain Cell Cycle Proteins--antagonists & inhibitors Cell Membrane Permeability Drug Design Drug Screening Assays, Antitumor HeLa Cells Humans Models, Molecular Organophosphates--chemical synthesis Protein Binding Protein Kinase Inhibitors--chemical synthesis Protein Serine-Threonine Kinases--antagonists & inhibitors Proto-Oncogene Proteins--antagonists & inhibitors Polo-Like Kinase 1