TY  - GEN
AU  - Huang,Jianying
AU  - Yang,Yang
AU  - Dib-Hajj,Sulayman D
AU  - van Es,Michael
AU  - Zhao,Peng
AU  - Salomon,Jody
AU  - Drenth,Joost P H
AU  - Waxman,Stephen G
TI  - Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain
SN  - 1529-2401
PY  - 2015///0107
KW  - Action Potentials
KW  - genetics
KW  - Amino Acid Sequence
KW  - Animals
KW  - Female
KW  - Ganglia, Spinal
KW  - physiopathology
KW  - HEK293 Cells
KW  - Humans
KW  - Leg
KW  - Male
KW  - Middle Aged
KW  - Molecular Sequence Data
KW  - Mutation
KW  - NAV1.7 Voltage-Gated Sodium Channel
KW  - chemistry
KW  - Neural Inhibition
KW  - Pain
KW  - Posterior Horn Cells
KW  - metabolism
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Structure-Activity Relationship
N1  - Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1523/JNEUROSCI.2773-14.2014
ER  -