Huang, Jianying

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Sep 2014 - 12328-40 p. digital

Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1529-2401

10.1523/JNEUROSCI.2773-14.2014 doi


Action Potentials--genetics
Amino Acid Sequence
Animals
Female
Ganglia, Spinal--physiopathology
HEK293 Cells
Humans
Leg
Male
Middle Aged
Molecular Sequence Data
Mutation--genetics
NAV1.7 Voltage-Gated Sodium Channel--chemistry
Neural Inhibition--genetics
Pain--physiopathology
Posterior Horn Cells--metabolism
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship