TY  - GEN
AU  - Tedeschi,Philip M
AU  - Kathari,Yamini K
AU  - Farooqi,Iqra N
AU  - Bertino,Joseph R
TI  - Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts
SN  - 1432-0843
PY  - 2015///0129
KW  - Aminopterin
KW  - administration & dosage
KW  - Animals
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - therapeutic use
KW  - Body Weight
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - Dose-Response Relationship, Drug
KW  - Drug Synergism
KW  - Female
KW  - Folic Acid Antagonists
KW  - Glutamates
KW  - pharmacology
KW  - Guanine
KW  - analogs & derivatives
KW  - Humans
KW  - Leucovorin
KW  - Mesothelioma
KW  - drug therapy
KW  - Methotrexate
KW  - Mice, Nude
KW  - Pemetrexed
KW  - Time Factors
KW  - Tumor Burden
KW  - Vitamin B Complex
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s00280-014-2580-z
ER  -