Lyon, Robert P

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates. [electronic resource] - Nature biotechnology Oct 2014 - 1059-62 p. digital

Publication Type: Journal Article

1546-1696

10.1038/nbt.2968 doi


Animals
Antibodies--chemistry
Antineoplastic Agents--chemistry
Cell Proliferation--drug effects
Excipients--chemistry
Female
Humans
Hydrogen-Ion Concentration
Hydrolysis
Immunoconjugates--chemistry
Maleimides--chemistry
Mice
Mice, SCID
Plasma
Xenograft Model Antitumor Assays