Chao, Ting-Ting

TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway. [electronic resource] - The Journal of pharmacology and experimental therapeutics Nov 2014 - 352-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.114.215418 doi


Animals
Apoptosis--drug effects
Autoantigens--metabolism
Carcinoma, Non-Small-Cell Lung--drug therapy
Caspase 3--metabolism
Caspase 9--metabolism
Cell Line, Tumor
Down-Regulation--drug effects
ErbB Receptors--metabolism
Erlotinib Hydrochloride
Humans
Intracellular Signaling Peptides and Proteins
Lung Neoplasms--drug therapy
Male
Membrane Proteins--metabolism
Mice
Mice, Nude
Phosphorylation--drug effects
Poly(ADP-ribose) Polymerases--metabolism
Protein Phosphatase 2--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Quinazolines--pharmacology