Hasui, Tomoaki <br/><br/>
Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.  [electronic resource] 

 -  Bioorganic & medicinal chemistry  Oct 2014 
 - 5428-45 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3391 
<br/><br/><label>Standard No.: </label>10.1016/j.bmc.2014.07.038  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Androgen Antagonists--administration & dosage<br/>Animals<br/>Antihypertensive Agents--administration & dosage<br/>COS Cells<br/>Chlorocebus aethiops<br/>Crystallography, X-Ray<br/>Desoxycorticosterone Acetate<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Humans<br/>Hypertension--chemically induced<br/>Male<br/>Mineralocorticoid Receptor Antagonists--administration & dosage<br/>Models, Molecular<br/>Molecular Structure<br/>Oxazines--administration & dosage<br/>Pyrazoles--administration & dosage<br/>Rats<br/>Rats, Wistar<br/>Receptors, Mineralocorticoid--agonists<br/>Structure-Activity Relationship