TY  - GEN
AU  - Gustafson,William Clay
AU  - Meyerowitz,Justin Gabriel
AU  - Nekritz,Erin A
AU  - Chen,Justin
AU  - Benes,Cyril
AU  - Charron,Elise
AU  - Simonds,Erin F
AU  - Seeger,Robert
AU  - Matthay,Katherine K
AU  - Hertz,Nicholas T
AU  - Eilers,Martin
AU  - Shokat,Kevan M
AU  - Weiss,William A
TI  - Drugging MYCN through an allosteric transition in Aurora kinase A
SN  - 1878-3686
PY  - 2014///1111
KW  - Allosteric Regulation
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Area Under Curve
KW  - Aurora Kinase A
KW  - antagonists & inhibitors
KW  - Catalytic Domain
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Crystallography, X-Ray
KW  - Humans
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, Nude
KW  - Mice, SCID
KW  - Models, Molecular
KW  - N-Myc Proto-Oncogene Protein
KW  - Neuroblastoma
KW  - drug therapy
KW  - Nuclear Proteins
KW  - Oncogene Proteins
KW  - Phenylurea Compounds
KW  - Phosphorylation
KW  - Protein Processing, Post-Translational
KW  - Protein Structure, Secondary
KW  - Proteolysis
KW  - Pyrimidines
KW  - S Phase Cell Cycle Checkpoints
KW  - Structure-Activity Relationship
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.ccr.2014.07.015
ER  -