TY  - GEN
AU  - Peng,Joanna Z
AU  - Denney,William S
AU  - Musser,Bret J
AU  - Liu,Rong
AU  - Tsai,Kuenhi
AU  - Fang,Lanyan
AU  - Reitman,Marc L
AU  - Troyer,Matthew D
AU  - Engel,Samuel S
AU  - Xu,Lei
AU  - Stoch,Aubrey
AU  - Stone,Julie A
AU  - Kowalski,Ken G
TI  - A semi-mechanistic model for the effects of a novel glucagon receptor antagonist on glucagon and the interaction between glucose, glucagon, and insulin applied to adaptive phase II design
SN  - 1550-7416
PY  - 2015///0707
KW  - Adult
KW  - Blood Glucose
KW  - analysis
KW  - Cross-Over Studies
KW  - Diabetes Mellitus, Type 2
KW  - blood
KW  - Double-Blind Method
KW  - Drug Administration Schedule
KW  - Drug Interactions
KW  - Female
KW  - Glucagon
KW  - administration & dosage
KW  - Glucose
KW  - metabolism
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Insulin
KW  - Male
KW  - Middle Aged
KW  - Models, Biological
KW  - Receptors, Glucagon
KW  - antagonists & inhibitors
N1  - Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1208/s12248-014-9648-x
ER  -