TY - GEN AU - Chen,Huadong AU - Fu,Junsheng AU - Chen,Hao AU - Hu,Yuhui AU - Soroka,Dominique N AU - Prigge,Justin R AU - Schmidt,Edward E AU - Yan,Feng AU - Major,Michael B AU - Chen,Xiaoxin AU - Sang,Shengmin TI - Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo SN - 1520-5010 PY - 2015///0519 KW - Alkylation KW - Animals KW - Catechols KW - chemistry KW - Cysteine KW - analysis KW - Epithelial Cells KW - cytology KW - Zingiber officinale KW - Glutamate-Cysteine Ligase KW - metabolism KW - Glutathione KW - HCT116 Cells KW - Heme Oxygenase-1 KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Kelch-Like ECH-Associated Protein 1 KW - Membrane Proteins KW - Mice KW - Mice, Knockout KW - NF-E2-Related Factor 2 KW - deficiency KW - Phosphorylation KW - drug effects KW - Protein Kinase Inhibitors KW - pharmacology KW - Reactive Oxygen Species KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1021/tx500211x ER -