TY - GEN AU - Lederer,Susan E TI - The challenges of challenge experiments SN - 1533-4406 PY - 2014///0902 KW - Ethics, Research KW - history KW - Female KW - Healthy Volunteers KW - History, 18th Century KW - History, 20th Century KW - History, 21st Century KW - Human Experimentation KW - ethics KW - Humans KW - Male KW - Smallpox KW - Smallpox Vaccine N1 - Publication Type: Historical Article; Journal Article UR - https://doi.org/10.1056/NEJMp1408554 ER -