TY - GEN AU - Wang,Zhiren AU - Wang,Yali AU - Li,Wenrui AU - Mao,Fei AU - Sun,Yang AU - Huang,Ling AU - Li,Xingshu TI - Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease SN - 1948-7193 PY - 2015///1102 KW - Alzheimer Disease KW - drug therapy KW - Amyloid beta-Peptides KW - metabolism KW - Animals KW - Antioxidants KW - chemical synthesis KW - Blood-Brain Barrier KW - Capillary Permeability KW - Cell Line, Tumor KW - Cell Survival KW - drug effects KW - Clioquinol KW - analogs & derivatives KW - Copper KW - toxicity KW - Drug Design KW - Drug Evaluation, Preclinical KW - Humans KW - Hydrogen Peroxide KW - Membranes, Artificial KW - Models, Biological KW - Nootropic Agents KW - Peptide Fragments KW - Protein Multimerization KW - Selenium Compounds KW - Swine N1 - Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/cn500119g ER -