TY  - GEN
AU  - Hegde,Sharath S
AU  - Hughes,Adam D
AU  - Chen,Yan
AU  - Steinfeld,Tod
AU  - Jasper,Jeffrey R
AU  - Lee,Tae-Weon
AU  - McNamara,Alexander
AU  - Martin,William J
AU  - Pulido-Rios,M Teresa
AU  - Mammen,Mathai
TI  - Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties
SN  - 1521-0103
PY  - 2014///1125
KW  - Adrenergic beta-2 Receptor Antagonists
KW  - adverse effects
KW  - Albuterol
KW  - analogs & derivatives
KW  - Animals
KW  - Bronchodilator Agents
KW  - CHO Cells
KW  - Carbamates
KW  - Cricetinae
KW  - Cricetulus
KW  - Cyclic AMP
KW  - metabolism
KW  - Drug Evaluation, Preclinical
KW  - Guinea Pigs
KW  - HEK293 Cells
KW  - Humans
KW  - Lung
KW  - drug effects
KW  - Muscarinic Antagonists
KW  - Muscle Relaxation
KW  - Muscle, Smooth
KW  - Protein Binding
KW  - Quinolones
KW  - Receptors, Adrenergic, beta
KW  - Receptors, Muscarinic
KW  - Salmeterol Xinafoate
KW  - Scopolamine Derivatives
KW  - pharmacokinetics
KW  - Tiotropium Bromide
KW  - Tissue Distribution
KW  - Trachea
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/jpet.114.216861
ER  -