Voight, Eric A <br/><br/>
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.  [electronic resource] 

 -  Journal of medicinal chemistry  Sep 2014 
 - 7412-24 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm500916t  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Analgesics--chemistry<br/>Animals<br/>Area Under Curve<br/>Body Temperature--drug effects<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>HEK293 Cells<br/>Humans<br/>Isoquinolines--chemistry<br/>Metabolic Clearance Rate<br/>Models, Chemical<br/>Molecular Structure<br/>Rats<br/>Structure-Activity Relationship<br/>TRPV Cation Channels--antagonists & inhibitors<br/>Urea--analogs & derivatives