Leone, Marc <br/><br/>
De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial.  [electronic resource] 

 -  Intensive care medicine  Oct 2014 
 - 1399-408 p.  digital 
<br/><br/> Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial 
<br/><br/><label>ISSN: </label>1432-1238 
<br/><br/><label>Standard No.: </label>10.1007/s00134-014-3411-8  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Anti-Bacterial Agents--administration & dosage<br/>Female<br/>France<br/>Humans<br/>Intensive Care Units--statistics & numerical data<br/>Length of Stay--statistics & numerical data<br/>Linear Models<br/>Male<br/>Microbial Sensitivity Tests<br/>Middle Aged<br/>Multivariate Analysis<br/>Proportional Hazards Models<br/>Sepsis--drug therapy<br/>Withholding Treatment