TY - GEN AU - Orejana,Lourdes AU - Barros-Miñones,Lucía AU - Jordan,Joaquin AU - Cedazo-Minguez,Angel AU - Tordera,Rosa M AU - Aguirre,Norberto AU - Puerta,Elena TI - Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse SN - 1758-535X PY - 2015///0720 KW - Aging KW - drug effects KW - Amyloid Precursor Protein Secretases KW - genetics KW - Animals KW - Aspartic Acid Endopeptidases KW - Calpain KW - metabolism KW - Cathepsin B KW - Cognition Disorders KW - drug therapy KW - Cyclin-Dependent Kinase 5 KW - Glial Fibrillary Acidic Protein KW - Glycogen Synthase Kinase 3 KW - Glycogen Synthase Kinases KW - Hippocampus KW - Mice KW - Models, Animal KW - Phosphodiesterase 5 Inhibitors KW - pharmacology KW - Phosphorylation KW - Piperazines KW - Proto-Oncogene Proteins c-akt KW - Purines KW - RNA, Messenger KW - Sildenafil Citrate KW - Sulfonamides N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1093/gerona/glu106 ER -