Orejana, Lourdes <br/><br/>
Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse.  [electronic resource] 

 -  The journals of gerontology. Series A, Biological sciences and medical sciences  Jun 2015 
 - 675-85 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1758-535X 
<br/><br/><label>Standard No.: </label>10.1093/gerona/glu106  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aging--drug effects<br/>Amyloid Precursor Protein Secretases--genetics<br/>Animals<br/>Aspartic Acid Endopeptidases--genetics<br/>Calpain--metabolism<br/>Cathepsin B--metabolism<br/>Cognition Disorders--drug therapy<br/>Cyclin-Dependent Kinase 5--metabolism<br/>Glial Fibrillary Acidic Protein--metabolism<br/>Glycogen Synthase Kinase 3--metabolism<br/>Glycogen Synthase Kinases--drug effects<br/>Hippocampus--drug effects<br/>Mice<br/>Models, Animal<br/>Phosphodiesterase 5 Inhibitors--pharmacology<br/>Phosphorylation--drug effects<br/>Piperazines--pharmacology<br/>Proto-Oncogene Proteins c-akt--drug effects<br/>Purines--pharmacology<br/>RNA, Messenger--metabolism<br/>Sildenafil Citrate<br/>Sulfonamides--pharmacology