TY  - GEN
AU  - Li,Huifang
AU  - Ban,Fuqiang
AU  - Dalal,Kush
AU  - Leblanc,Eric
AU  - Frewin,Kate
AU  - Ma,Dennis
AU  - Adomat,Hans
AU  - Rennie,Paul S
AU  - Cherkasov,Artem
TI  - Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor
SN  - 1520-4804
PY  - 2015///0207
KW  - Androgen Receptor Antagonists
KW  - chemical synthesis
KW  - Animals
KW  - Antineoplastic Agents
KW  - Benzamides
KW  - Binding Sites
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Computer Simulation
KW  - DNA
KW  - metabolism
KW  - Databases, Chemical
KW  - Drug Resistance, Neoplasm
KW  - Humans
KW  - Imidazoles
KW  - Male
KW  - Molecular Conformation
KW  - Molecular Docking Simulation
KW  - Morpholines
KW  - Mutation
KW  - Nitriles
KW  - Phenylthiohydantoin
KW  - analogs & derivatives
KW  - Prostate-Specific Antigen
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Pyrvinium Compounds
KW  - chemistry
KW  - Rats
KW  - Receptors, Androgen
KW  - genetics
KW  - Structure-Activity Relationship
KW  - Thiazoles
KW  - Thiophenes
KW  - Transcription, Genetic
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1021/jm500802j
ER  -