TY - GEN AU - Berger,Carola AU - Romero-Brey,Inés AU - Radujkovic,Danijela AU - Terreux,Raphael AU - Zayas,Margarita AU - Paul,David AU - Harak,Christian AU - Hoppe,Simone AU - Gao,Min AU - Penin,Francois AU - Lohmann,Volker AU - Bartenschlager,Ralf TI - Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication SN - 1528-0012 PY - 2015///0130 KW - Antiviral Agents KW - chemistry KW - Binding Sites KW - Carbamates KW - Cell Line, Tumor KW - Cell Membrane KW - drug effects KW - Drug Design KW - Drug Resistance, Viral KW - Hepacivirus KW - Hepatocytes KW - Host-Pathogen Interactions KW - Humans KW - Imidazoles KW - Minor Histocompatibility Antigens KW - Molecular Docking Simulation KW - Molecular Structure KW - Mutation KW - Phosphotransferases (Alcohol Group Acceptor) KW - metabolism KW - Protease Inhibitors KW - Protein Conformation KW - Protein Multimerization KW - Pyrrolidines KW - Structure-Activity Relationship KW - Time Factors KW - Transfection KW - Valine KW - analogs & derivatives KW - Viral Nonstructural Proteins KW - antagonists & inhibitors KW - Virus Replication N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1053/j.gastro.2014.07.019 ER -