Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication. [electronic resource]
- Gastroenterology Nov 2014
- 1094-105.e25 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1528-0012
10.1053/j.gastro.2014.07.019 doi
Antiviral Agents--chemistry Binding Sites Carbamates Cell Line, Tumor Cell Membrane--drug effects Drug Design Drug Resistance, Viral Hepacivirus--drug effects Hepatocytes--drug effects Host-Pathogen Interactions Humans Imidazoles--chemistry Minor Histocompatibility Antigens Molecular Docking Simulation Molecular Structure Mutation Phosphotransferases (Alcohol Group Acceptor)--metabolism Protease Inhibitors--chemistry Protein Conformation Protein Multimerization Pyrrolidines Structure-Activity Relationship Time Factors Transfection Valine--analogs & derivatives Viral Nonstructural Proteins--antagonists & inhibitors Virus Replication--drug effects