TY  - GEN
AU  - Dail,Monique
AU  - Wong,Jason
AU  - Lawrence,Jessica
AU  - O'Connor,Daniel
AU  - Nakitandwe,Joy
AU  - Chen,Shann-Ching
AU  - Xu,Jin
AU  - Lee,Leslie B
AU  - Akagi,Keiko
AU  - Li,Qing
AU  - Aster,Jon C
AU  - Pear,Warren S
AU  - Downing,James R
AU  - Sampath,Deepak
AU  - Shannon,Kevin
TI  - Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia
SN  - 1476-4687
PY  - 2014///1107
KW  - Animals
KW  - Benzamides
KW  - pharmacology
KW  - Clone Cells
KW  - drug effects
KW  - Diphenylamine
KW  - analogs & derivatives
KW  - Down-Regulation
KW  - Drug Resistance, Neoplasm
KW  - Drug Synergism
KW  - Genes, ras
KW  - genetics
KW  - Indazoles
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
KW  - drug therapy
KW  - Protein Kinase Inhibitors
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins c-akt
KW  - metabolism
KW  - Receptor, Notch1
KW  - chemistry
KW  - Signal Transduction
KW  - Sulfonamides
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature13495
ER  -