TY - GEN AU - Ryoo,Jeongmin AU - Choi,Jongsu AU - Oh,Changhoon AU - Kim,Sungchul AU - Seo,Minji AU - Kim,Seok-Young AU - Seo,Daekwan AU - Kim,Jongkyu AU - White,Tommy E AU - Brandariz-Nuñez,Alberto AU - Diaz-Griffero,Felipe AU - Yun,Cheol-Heui AU - Hollenbaugh,Joseph A AU - Kim,Baek AU - Baek,Daehyun AU - Ahn,Kwangseog TI - The ribonuclease activity of SAMHD1 is required for HIV-1 restriction SN - 1546-170X PY - 2014///1010 KW - Autoimmune Diseases of the Nervous System KW - genetics KW - Base Sequence KW - Binding Sites KW - CD4-Positive T-Lymphocytes KW - Cell Line, Tumor KW - HIV Infections KW - HIV-1 KW - physiology KW - HeLa Cells KW - Humans KW - Macrophages KW - Monomeric GTP-Binding Proteins KW - Mutation KW - Nervous System Malformations KW - Phosphorylation KW - RNA Interference KW - RNA, Small Interfering KW - RNA, Viral KW - Ribonucleases KW - metabolism KW - SAM Domain and HD Domain-Containing Protein 1 KW - Sequence Analysis, RNA KW - Virus Replication N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nm.3626 ER -