Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity. [electronic resource]
- AIDS (London, England) Sep 2014
- 2213-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5571
10.1097/QAD.0000000000000399 doi
Anti-HIV Agents--metabolism Cells, Cultured Cyclin-Dependent Kinase 2--metabolism Cyclin-Dependent Kinase 6--metabolism DNA, Viral--analysis HIV-1--physiology Humans Leukocytes, Mononuclear--virology Monomeric GTP-Binding Proteins--antagonists & inhibitors Piperazines--metabolism Protein Kinase Inhibitors--metabolism Pyridines--metabolism Real-Time Polymerase Chain Reaction Reverse Transcription SAM Domain and HD Domain-Containing Protein 1