PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. [electronic resource]
- Anti-cancer drugs Nov 2014
- 1129-40 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5741
10.1097/CAD.0000000000000148 doi
Adenocarcinoma--blood supply Aged Antineoplastic Agents--pharmacology Cell Line, Tumor Cell Movement--drug effects Cell Proliferation--drug effects Female Human Umbilical Vein Endothelial Cells--physiology Humans Indoles--pharmacology Male Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Middle Aged Multiprotein Complexes--metabolism Neoplasm Invasiveness--pathology Neoplasm Metastasis Neovascularization, Pathologic--metabolism Oncogene Protein v-akt--metabolism Phosphatidylinositol 3-Kinases--metabolism Phosphorylation Purines--pharmacology Ribosomal Protein S6 Kinases, 70-kDa--metabolism Signal Transduction Stomach Neoplasms--blood supply TOR Serine-Threonine Kinases--metabolism