Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Sep 2014
- 1532-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.114.059394 doi
Acetaminophen--adverse effects Adaptor Proteins, Signal Transducing--metabolism Animals Carboxylic Ester Hydrolases--metabolism Cell Proliferation--physiology Chemical and Drug Induced Liver Injury--metabolism Cyclin D1--metabolism Cyclin-Dependent Kinase 4--metabolism Cyclin-Dependent Kinase Inhibitor p21--metabolism Cytoskeletal Proteins--metabolism Hepatocytes--metabolism Kelch-Like ECH-Associated Protein 1 Liver--drug effects Liver Regeneration--physiology Male Mice Mice, Inbred C57BL NF-E2-Related Factor 2--metabolism Proliferating Cell Nuclear Antigen--metabolism Signal Transduction--physiology Tumor Suppressor Protein p53--metabolism