TY  - GEN
AU  - Felding,Jakob
AU  - Sørensen,Morten D
AU  - Poulsen,Tina D
AU  - Larsen,Jens
AU  - Andersson,Christina
AU  - Refer,Pia
AU  - Engell,Karen
AU  - Ladefoged,Lotte G
AU  - Thormann,Thorsten
AU  - Vinggaard,Anne Marie
AU  - Hegardt,Pontus
AU  - Søhoel,Anders
AU  - Nielsen,Simon Feldbæk
TI  - Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis
SN  - 1520-4804
PY  - 2014///1021
KW  - Acetamides
KW  - chemical synthesis
KW  - Crystallography, X-Ray
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - metabolism
KW  - Dermatitis, Atopic
KW  - drug therapy
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Humans
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Phosphodiesterase 4 Inhibitors
KW  - Pyridines
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Review
UR  - https://doi.org/10.1021/jm500378a
ER  -