Felding, Jakob <br/><br/>
Discovery and early clinical development of 2--N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2014 
 - 5893-903 p.  digital 
<br/><br/> Publication Type: Journal Article; Review 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm500378a  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetamides--chemical synthesis<br/>Crystallography, X-Ray<br/>Cyclic Nucleotide Phosphodiesterases, Type 4--metabolism<br/>Dermatitis, Atopic--drug therapy<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Humans<br/>Models, Molecular<br/>Molecular Structure<br/>Phosphodiesterase 4 Inhibitors--chemical synthesis<br/>Pyridines--chemical synthesis<br/>Structure-Activity Relationship