TY - GEN AU - Ginzkey,Christian AU - Steussloff,Gudrun AU - Koehler,Christian AU - Hackenberg,Stephan AU - Richter,Elmar AU - Hagen,Rudolf AU - Kleinsasser,Norbert H TI - Nicotine causes genotoxic damage but is not metabolized during long-term exposure of human nasal miniorgan cultures SN - 1879-3169 PY - 2014///0908 KW - Adolescent KW - Adult KW - Aryl Hydrocarbon Hydroxylases KW - metabolism KW - Comet Assay KW - Cotinine KW - Cytochrome P-450 CYP2A6 KW - DNA Damage KW - Female KW - Gas Chromatography-Mass Spectrometry KW - Humans KW - Male KW - Methyl Methanesulfonate KW - Middle Aged KW - Mutagens KW - Nasal Mucosa KW - Nicotine KW - Nicotinic Agonists KW - Organ Culture Techniques KW - Receptors, Nicotinic KW - biosynthesis KW - Smoking KW - Young Adult N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.toxlet.2014.06.842 ER -