Thiele, Jan R

Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy. [electronic resource] - Circulation Jul 2014 - 35-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/CIRCULATIONAHA.113.007124 doi


Animals
Anti-Inflammatory Agents--pharmacology
Biopolymers
C-Reactive Protein--chemistry
Carrier Proteins--chemistry
Cell Adhesion--drug effects
Cell Membrane--drug effects
Chemotaxis, Leukocyte
Complement Activation
Endothelial Cells--drug effects
Hexanes--pharmacology
Humans
Inflammation--drug therapy
Leukocyte Rolling--drug effects
Lipopolysaccharides--toxicity
Lysophosphatidylcholines--metabolism
Male
Membrane Lipids--metabolism
Muscle, Skeletal--blood supply
Myocardial Infarction--metabolism
Myositis--chemically induced
Phospholipase A2 Inhibitors--pharmacology
Phospholipases A2--metabolism
Phosphorylcholine--analogs & derivatives
Protein Structure, Quaternary
Random Allocation
Rats
Rats, Wistar
Receptors, IgG--physiology
Reperfusion Injury--metabolism