TY  - GEN
AU  - Van Schaeybroeck,Sandra
AU  - Kalimutho,Murugan
AU  - Dunne,Philip D
AU  - Carson,Robbie
AU  - Allen,Wendy
AU  - Jithesh,Puthen V
AU  - Redmond,Keara L
AU  - Sasazuki,Takehiko
AU  - Shirasawa,Senji
AU  - Blayney,Jaine
AU  - Michieli,Paolo
AU  - Fenning,Cathy
AU  - Lenz,Heinz-Josef
AU  - Lawler,Mark
AU  - Longley,Daniel B
AU  - Johnston,Patrick G
TI  - ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer
SN  - 2211-1247
PY  - 2015///0416
KW  - ADAM Proteins
KW  - genetics
KW  - ADAM17 Protein
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Cell Proliferation
KW  - Colorectal Neoplasms
KW  - drug therapy
KW  - Drug Resistance, Neoplasm
KW  - Female
KW  - HCT116 Cells
KW  - Humans
KW  - MAP Kinase Kinase Kinases
KW  - antagonists & inhibitors
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-met
KW  - metabolism
KW  - Proto-Oncogene Proteins p21(ras)
KW  - STAT3 Transcription Factor
KW  - Signal Transduction
KW  - Xenograft Model Antitumor Assays
KW  - ras Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.celrep.2014.05.032
ER  -