Zhu, Jianqiong
Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. [electronic resource]
- Blood Aug 2014
- 1146-56 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
ISSN: 1528-0020
Standard No.: 10.1182/blood-2013-10-534842 doi
Subjects--Topical Terms: Antineoplastic Agents--pharmacology Apoptosis--drug effects Binding Sites--genetics Blotting, Western Cell Cycle Checkpoints--drug effects Cells, Cultured Fetal Hemoglobin--genetics GTP-Binding Protein alpha Subunits, Gi-Go--metabolism Gene Expression--drug effects Humans Hydroxyurea--pharmacology JNK Mitogen-Activated Protein Kinases--metabolism K562 Cells Monomeric GTP-Binding Proteins--genetics NF-kappa B--metabolism Promoter Regions, Genetic--genetics Proto-Oncogene Proteins c-jun--metabolism RNA Interference Reverse Transcriptase Polymerase Chain Reaction Signal Transduction--drug effects ets-Domain Protein Elk-1--metabolism gamma-Globins--genetics