TY  - GEN
AU  - Zhang,Jiazhen
AU  - Clark,Kristopher
AU  - Lawrence,Toby
AU  - Peggie,Mark W
AU  - Cohen,Philip
TI  - An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
SN  - 1470-8728
PY  - 2014///0921
KW  - Amino Acid Substitution
KW  - Animals
KW  - Cells, Cultured
KW  - Embryo, Mammalian
KW  - cytology
KW  - Enzyme Activation
KW  - drug effects
KW  - Gene Knock-In Techniques
KW  - HEK293 Cells
KW  - Humans
KW  - I-kappa B Kinase
KW  - antagonists & inhibitors
KW  - Intracellular Signaling Peptides and Proteins
KW  - genetics
KW  - MAP Kinase Kinase Kinases
KW  - Mice
KW  - Mice, Transgenic
KW  - Mutant Proteins
KW  - Phosphorylation
KW  - Protein Interaction Domains and Motifs
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Protein Processing, Post-Translational
KW  - Recombinant Proteins
KW  - chemistry
KW  - Serine
KW  - metabolism
KW  - Ubiquitination
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1042/BJ20140444
ER  -