TY  - GEN
AU  - Ling,Chenyu
AU  - Fu,Liqiang
AU  - Gao,Suo
AU  - Chu,Wenjing
AU  - Wang,Hui
AU  - Huang,Yanqin
AU  - Chen,Xiaoyan
AU  - Yang,Yushe
TI  - Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents
SN  - 1520-4804
PY  - 2014///0820
KW  - Aminopyridines
KW  - chemical synthesis
KW  - Animals
KW  - Anti-Bacterial Agents
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Diterpenes
KW  - Drug Design
KW  - Drug Resistance, Bacterial
KW  - Drug Stability
KW  - Female
KW  - Humans
KW  - Hydrophobic and Hydrophilic Interactions
KW  - In Vitro Techniques
KW  - Male
KW  - Methicillin-Resistant Staphylococcus aureus
KW  - drug effects
KW  - Mice
KW  - Microbial Sensitivity Tests
KW  - Polycyclic Compounds
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Solubility
KW  - Staphylococcal Infections
KW  - drug therapy
KW  - Staphylococcus
KW  - Streptococcus
KW  - Structure-Activity Relationship
KW  - Sulfides
KW  - Pleuromutilins
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm500312x
ER  -