Ling, Chenyu <br/><br/>
Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents.  [electronic resource] 

 -  Journal of medicinal chemistry  Jun 2014 
 - 4772-95 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm500312x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aminopyridines--chemical synthesis<br/>Animals<br/>Anti-Bacterial Agents--chemical synthesis<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 CYP3A Inhibitors<br/>Diterpenes--chemical synthesis<br/>Drug Design<br/>Drug Resistance, Bacterial<br/>Drug Stability<br/>Female<br/>Humans<br/>Hydrophobic and Hydrophilic Interactions<br/>In Vitro Techniques<br/>Male<br/>Methicillin-Resistant Staphylococcus aureus--drug effects<br/>Mice<br/>Microbial Sensitivity Tests<br/>Polycyclic Compounds<br/>Rats<br/>Rats, Sprague-Dawley<br/>Solubility<br/>Staphylococcal Infections--drug therapy<br/>Staphylococcus--drug effects<br/>Streptococcus--drug effects<br/>Structure-Activity Relationship<br/>Sulfides--chemical synthesis<br/>Pleuromutilins