Sampson, Peter B <br/><br/>
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3�'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 2015 
 - 130-46 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm5005336  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Biological Availability<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Dose-Response Relationship, Drug<br/>Drug Design<br/>Drug Discovery<br/>Drug Screening Assays, Antitumor<br/>HCT116 Cells<br/>Humans<br/>Indoles--chemistry<br/>MCF-7 Cells<br/>Mice<br/>Models, Chemical<br/>Molecular Structure<br/>Neoplasms--drug therapy<br/>Protein Kinase Inhibitors--chemistry<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Rats<br/>Spiro Compounds--chemistry<br/>Structure-Activity Relationship<br/>Xenograft Model Antitumor Assays