TY - GEN AU - O'Sullivan,Ciara C AU - Connolly,Roisin M TI - Pertuzumab and its accelerated approval: evolving treatment paradigms and new challenges in the management of HER2-positive breast cancer SN - 0890-9091 PY - 2014///0618 KW - Animals KW - Antibodies, Monoclonal, Humanized KW - pharmacokinetics KW - Antineoplastic Agents KW - Breast Neoplasms KW - drug therapy KW - Chemotherapy, Adjuvant KW - Drug Approval KW - Female KW - Humans KW - Molecular Targeted Therapy KW - Neoadjuvant Therapy KW - Receptor, ErbB-2 KW - antagonists & inhibitors KW - Signal Transduction KW - drug effects KW - Time Factors KW - Treatment Outcome KW - United States KW - United States Food and Drug Administration N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review ER -