Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. [electronic resource]
- PloS one 2014
- e97942 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1932-6203
10.1371/journal.pone.0097942 doi
Animals Anthracenes Blotting, Western DNA Methylation--genetics DNA Primers--genetics DNA-Binding Proteins--metabolism Fluorescence Resonance Energy Transfer Fluorescent Antibody Technique Focal Adhesion Kinase 2--metabolism Gene Expression Regulation--physiology Mechanotransduction, Cellular--physiology Mice Multiprotein Complexes--biosynthesis Osteocytes--metabolism Real-Time Polymerase Chain Reaction Shear Strength Stress, Mechanical src-Family Kinases--metabolism