Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. [electronic resource]
- Cell reports May 2014
- 999-1008 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2014.04.014 doi
Adenocarcinoma--drug therapy Adenocarcinoma of Lung Afatinib Animals Antibodies, Monoclonal, Humanized--administration & dosage Antineoplastic Combined Chemotherapy Protocols--pharmacology Cell Line, Tumor Cetuximab Drug Resistance, Neoplasm ErbB Receptors--genetics Humans Lung Neoplasms--drug therapy Mechanistic Target of Rapamycin Complex 1 Mice Mice, Nude Mice, Transgenic Multiprotein Complexes--metabolism Mutation Quinazolines--administration & dosage Random Allocation TOR Serine-Threonine Kinases--metabolism Xenograft Model Antitumor Assays