Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. [electronic resource]
- Cell death & disease May 2014
- e1209 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/cddis.2014.175 doi
AMP-Activated Protein Kinases--metabolism Animals Dose-Response Relationship, Drug Down-Regulation Enzyme Activation Gestational Age HeLa Cells Hippocampus--drug effects Humans Hypoglycemic Agents--pharmacology Metformin--pharmacology Mice Mice, Inbred C57BL Neurons--drug effects Phosphorylation Primary Cell Culture Protein Kinase Inhibitors--pharmacology Protein Phosphatase 2--metabolism Serine Signal Transduction--drug effects TOR Serine-Threonine Kinases--antagonists & inhibitors Time Factors Transfection alpha-Synuclein--genetics