TY - GEN AU - Li,Baomin AU - Iglesias-Pedraz,Juan Manuel AU - Chen,Leng-Ying AU - Yin,Fei AU - Cadenas,Enrique AU - Reddy,Sita AU - Comai,Lucio TI - Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells SN - 1474-9726 PY - 2014///1029 KW - Animals KW - Antioxidants KW - pharmacology KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Cell Respiration KW - Cellular Senescence KW - DNA Damage KW - Down-Regulation KW - Energy Metabolism KW - Exodeoxyribonucleases KW - genetics KW - Gene Knockdown Techniques KW - Glutathione KW - metabolism KW - Homeostasis KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Macromolecular Substances KW - Mice KW - Mitochondria KW - Neoplasms KW - Niacinamide KW - Oxidation-Reduction KW - Oxidative Stress KW - Reactive Oxygen Species KW - RecQ Helicases KW - Werner Syndrome KW - Werner Syndrome Helicase N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1111/acel.12181 ER -